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Excess Length of Stay Associated with Postoperative Sepsis

Basic Facts

Stage of development

Tested

Potential or current usage

Postoperative sepsis is associated with a range of complications following surgery, including greater length of stay among those with postoperative sepsis compared to surgical patients with the same characteristics. This measure is suitable as a marker of healthcare quality and safety, particularly to assess the impact of interventions to reduce postoperative harm.

Brief overview of the measure

General description

This measure was selected to provide baseline information about the excess length of stay (LOS) associated with postoperative sepsis, enabling the calculation of changes over time in this measure.

Rationale for selection

Postoperative sepsis has been shown to result in, among other things, increased mortality rates and increased hospital stay among surgical patients. Postoperative sepsis can be prevented through the appropriate use prophylactic antibiotics, good surgical site preparation, careful and sterile surgical techniques, and good postoperative care.

Type of measure

Outcomes

Domain(s) of quality

Safety

Application and interpretation of the measure

Stated intent of the measure

To measure the number of excess length of stay associated with postoperative sepsis in order to assess the impact of healthcare quality and safety initiatives in New Zealand.

Caveats - Considerations

The main caveat of this measure is the sparseness of numerator data, or in other words, the number of events with postoperative sepsis. There are too few events to present meaningful postoperative sepsis data at the local level for the purpose of baseline estimation.

Links to other measures

This measure uses the numerator and denominator data assembled to calculate incidence rates of postoperative sepsis (see linked specification). This measure is also linked to the Health Quality and Safety Commission’s broader set of postoperative harm Quality and Safety Markers.

Level of health care delivery/setting

This measure is focused on postoperative harm following an operating room or anesthetic procedure and prior to discharge.

Target population

This measure focuses on the total population.

Stratification by vulnerable populations

In order to adjust for risks associated with adverse surgical outcomes, the calculation of the excess length of stay requires the stratification of data by age, sex, admission type and diagnostic related group.

Possible sources of bias or confounding

There can be wide variation in hospital stay outcomes by admission type, the type of healthcare received, and by patient factors such as co-morbidities. These are referred to as risks, and need to be adjusted for when assessing postoperative harm. Statistical methods such as regression modeling are commonly used to risk-adjust estimates of adverse healthcare outcomes. However, these methods can produce results that are negatively influenced by small numerator counts, lack of clinical data, and misclassification of the adverse outcomes associated with healthcare. An approach more recently used is to match individual cases and controls by these risk adjustment variables. In the analyses described here, confounding has been controlled for by grouping (stratifying) observed and expected data by these risk adjustment variables and then matching these observed and expected grouped data to estimate the excess number of deaths. Regression modeling maybe used in future analyses once larger count data are available.

Calculation of the measure

Output of calculation

The output of this calculation is the excess LOS associated with postoperative sepsis. The calculation of this measure is described below.

Numerator description

This measure uses the numerator and denominator data assembled to calculate incidence rates of postoperative sepsis (see the specifications for incidence rates of postoperative sepsis). This was calculated by using the formula E = o – e where E is the excess LOS associated with postoperative sepsis, o is the average LOS observed in the postoperative sepsis group, and e is the average LOS expected in the postoperative sepsis group. A number of steps were taken to calculate the excess LOS. First, total LOS data for postoperative sepsis group (i.e. numerator data) were grouped by age, sex, admission type and diagnostic related group (DRG) variables. The total number of events in the postoperative sepsis group for each stratified group was also calculated. Second, total LOS data for the non-postoperative sepsis group (i.e. denominator data) were grouped by age, sex, admission type and DRG variables. The total number of events in this denominator set for each stratified group was also calculated. Then, a national average was calculated for each stratified group by dividing the total LOS by the total number of events in each stratified group. Third, the grouped data for patients with sepsis were matched by age, sex, admission type and DRG to those patients without sepsis. Then, the expected total LOS for patients with postoperative sepsis was then calculated by multiplying the national average for each stratified group with the total number of events of postoperative sepsis (from the numerator data) in each stratified group. Fourth, the average observed and expected LOS for patients with postoperative sepsis was calculated. Fifth, the excess LOS was calculated as the difference between the average observed LOS and the average expected LOS for patients with postoperative sepsis.

Time period

12 months

Criteria/standard for optimal performance

Variables used in risk adjustment vary across studies of postoperative sepsis. For the purposes of the QSM outcome measures we have used age, sex, admission type and DRG. Other variables such as principal diagnosis chapter and co-morbidities, applied in risk adjusted estimates from the Health Roundtable, may be used in future analyses.

Data source

National minimum dataset (NMDS) 2010/11, available from the Ministry of Health.

Method of extraction

NMDS data were imported into Microsoft Access 2010. Queries were developed separately for extracting denominator data and numerator data. Calculations of expected LOS and the matching of grouped data were undertaken in Microsoft Excel 2010.

Appraisal of the measure

Evidence of feasibility and reliability of implementation

Reliability - The measure has been demonstrated to be reliable (i.e. free from random error)., Interpretation - The measure allows unambiguous interpretation of better or worse performance., Data extraction - Data collection specifications for the measure are well defined., Data sources - Required data elements for the measure can be obtained from existing data sources., Availability of data - Required data elements for the measure can be gathered during routine practice activities, IT software - Existing IT software is sufficient for data collection., Validity - The measure has been demonstrated to be valid (i.e. it measures what it purports to).

Development approach

Availability of evidence to support application of the measure There is currently limited knowledge internationally on the adverse effects of postoperative harm, including examination of excess length of stay and excess mortality. However, a number of recent patient safety studies and reports have assessed the excess LOS associated with postoperative sepsis. These studies have estimated the excess LOS for postoperative sepsis to range from between 5 and 18. Evidence of feasibility and reliability of implementation The feasibility testing showed that it was possible using group numerator and denominator data derived from NDMS data to estimate the excess LOS associated with postoperative sepsis. Few similar analyses have been undertaken in New Zealand to compare findings. Future analyses will focus on testing the selection of risk-adjustment variables to provide a best estimate of excess LOS associated with postoperative sepsis.

Other items

Owner details

Reference number

2738

Date of entry to library

2012-11-09 15:06:57

Owner (Organisation name)

Health Quality and Safety Commission

Owner (Email contact)

richard.hamblin@hqsc.govt.nz

Creator (Organisation name)

Health Quality and Safety Commission

Creator (Email contact)